(#first author, *corresponding author)


  • Wang X#, Ai J#, Li X#, Zhao X#, Wu J#, Zhang H#, He X#, Zhao C, Qiao R, Li M, Cui Y, Hu Z*, Xu C*, Zhang W* and Wang P*, (2022) Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera, Cell Discovery, 8(1):110.    

  • Ai J#, Guo J#, Zhang H#, Zhang Y#, Yang H#, Lin K#, Song J#, Fu Z#, Fan M#, Zhang Q, Wang H, Zhao Y, He Z, Cui A, Zhou Y, Wu J, Zhou M, Yuan G, Kang B, Zhao N, Xu Y, Zhu M, Wang Y, Zhang Z, Jiang N*, Qiu C*, Xu C*, Zhang W*, (2022) Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling, Cell Discovery, 8(1):114.    

  • Wang Q, Zhu T, Miao N, Qu Y, Wang Z, Chao Y, Wang J, Wu W, Xu X, Xu C, Xia L, Wang F (2022) Disulfiram bolsters T-cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling, The EMBO Journal, 41(16):e110636    


  • Li T#, Cai H#, Zhao Y#, Li  Y#, Lai  Y#, Yao H#, Liu L# , Sun Z#, Vlissingen M, Kuiken T, GeurtsvanKessel C , Zhang N , Zhou B , Lu L , Gong Y, Qin W , Mondal M , Duan B , Xu S , Richard A, Raoul H , Chen J, Xu C, Wu L , Zhou H , Huang Z , Zhang X , Li J , Wang Y , Bi Y , Rockx B , Chen J*, Meng F*, Lavillette D*, Li D* (2021) Uncovering a conserved vulnerability site in SARS-CoV-2 by a human antibody, EMBO Molecular Medicine, 13(12):e14544    

  • Wen M#*, Cao Y#, Wu B#, Xiao T, Cao R, Wang Q, Liu X, Xue H, Yu Y, Lin J, Xu C, Xu J, OuYang B* (2021)PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain,  Nature Communications, 12(1):5106    

  • Xu Y, Ma J, Luo H, Shi Y, Liu H, Sun A, Xu C, Ji H, Liu X (2021) Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice, European Journal of Immunology, 51(7):1698-1714    

  • Wang H*, Song X, Shen L, Wang X, Xu C* (2021) Exploiting T cell signaling to optimize engineered T cell therapies, Trends in Cancer, S2405-8033(21)00224-7    

  • Delgoffe G, Xu C, Mackall C, Green M, Gottschalk S, Speiser D, Zehn D, Beavis P (2021) The role of exhaustion in CAR T cell therapy, Cancer Cell, 39: 888    


  • Li W#, Qiu S#, Jian C#, Jiang S, Chen W, Jiang J, Wang F, Si W, Shu Y, Wei P, Fan G, Tian R, Wu H*, Xu C*, Wang H* (2020) Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy, Immunity, 53(2):456-470.e6.    

  • Wu W#, Zhou Q#, Masubuchi T#, Shi X#, Li H, Xu X, Huang M, Meng L, He X, Zhu H, Gao S, Zhang N, Jing R, Sun J, Wang H, Hui E*, Wong C*, Xu C* (2020) Multiple signaling roles of CD3e and its application in CAR-T cell therapy, Cell, 182(4): 855-871.e23.    

  •  He X, Xu C*  (2020) Immune checkpoint signaling and cancer immunotherapy. Cell Research, 30(8): 660-669, 2020.    

  • Guo J, Xu C* (2020) Screening for the next-generation T cell therapies. Cancer Cell, 37(5): 627-629.    

  • Fan Z#, Tian Y#, Chen Z, Liu L, Zhou Q, He J, Coleman J, Dong C, Li N, Huang J, Xu C, Zhang Z, Gao S, Zhou P*, Ding K*, Chen L* (2020) Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO molecular medicine, e11571.    

  • He X, Xu C(2020) PD-1: A Driver or Passenger of T Cell Exhaustion? Molecular Cell. 77(5):930-931    

  • Xu X#, Li H#, Xu, C* (2020) Structural understanding of T cell receptor triggering. Cell Mol Immunol, 17(3): 193-202.    

  • Huang B, Song B, Xu C* (2020) Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities. Nature Metabolism, 2: 132-141.    


  • Li H*, Yan C, Guo J, Xu C* (2019) Ionic protein–lipid interactions at the plasma membrane regulate the structure and function of immunoreceptors. Advances in Immunology, 144 pp 65-85    

  • Wu P, Zhang T, Liu B, Fei P, Cui L, Qin R, Zhu H, Yao D, Martinez R, Hu W, An C, Zhang Y, Liu J, Shi J, Fan J, Yin W, Sun J, Zhou C, Zeng X, Xu C, Wang J, Evavold B, Zhu C, Chen W*, Lou J* (2019) Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition. Molecular Cell. 73(5):1015-1027    


  • Meng X#, Liu X#, Guo X, Jiang S, Chen T, Hu Z, Liu H, Bai Y, Xue M, Hu R, Sun SC, Liu X, Zhou P, Huang X, Wei L, Yang W, Xu C* (2018) FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells. Nature. 564 (7734): 130-135    

  • Guo J#, Zhang Y#, Li H#, Chu H#, Wang Q, Jiang S, Li Y, Shen H, Li G*, Chen J*, Xu C* (2018) Intramembrane ionic protein-lipid interaction regulates integrin structure and function. PLoS Biology, 16(11):e2006525, 2018.    

  • Chen X#, Sun X#, Yang W#, Yang B#, Zhao X, Chen S, He L, Chen H, Yang C, Xiao L, Chang Z, Guo J, He J, Zhang F, Zheng F, Hu Z, Yang Z, Lou J, Zheng W, Qi H, Xu C, Zhang H, Shan H, Zhou XJ, Wang Q, Shi Y, Lai L, Li Z*, Liu W* (2018) An autoimmune disease variant of IgG1 modulates B cell activation and differentiation. Science. 362 (6415): 700-705    

  • Wang J, Yan C, Xu C, Chua B, Li P*, Chen F* (2018) Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids. Journal of Biological Chemistry. 293(50):19330-19343    


  • Guo X#, Yan C#, Li H#, Huang W#, Shi X, Huang M, Wang Y, Pan W, Cai M, Li L, Wu W, Bai Y, Zhang C, Liu Z, Wang X, Zhang F X, Tang C, Wang H, Liu W, Ouyang B, Catherine C Wong, Cao Y*, Xu C* (2017) Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor. Cell Res. 27(4): 505-525    

  • Li L#, Guo X#, Shi X#, Li C#, Wu W, Yan C, Wang H, Li H, Xu C* (2017) Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling. Proc Natl Acad Sci U S A. PLUS 114(29): E5891-E5899    

  • Wang H, Wang S, Li C, Li H, Mao Y, Liu W, Xu C*, Long D* (2017) Probing Transient Release of Membrane-Sequestered Tyrosine-Based Signaling Motif by Solution NMR Spectroscopy. J Phys Chem Lett. 8(16): 3765-3769    

  • Yang W#, Pan W#, Chen S#, Trendel N#, Jiang S#, Xiao F, Xue M, Wu W, Peng Z, Li X, Ji H, Liu X, Jiang H, Wang H, Shen H, Dushek O*, Li H*, Xu C* (2017) Dynamic regulation of CD28 conformation and signaling by charged lipids and ions. Nat Struct Mol Biol. 24(12):1081-1092    

  • Bietz A#, Zhu H#, Xue M, Xu C* (2017) Cholesterol Metabolism in T Cells, Front Immunol. 8:1664    

  • Xu C, Xie H, Guo X, Gong H, Liu L, Qi H, Xu C, Liu W*. A PIP2-derived amplification loop fuels the sustained initiation of B cell activation. Sci Immunol, 2(17), 2017    


  • Cui Y#, Chen X#, Zhang J, Sun X, Liu H, Bai L, Xu C, Liu X* (2016) Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis. Cell Rep. 15(2): 256-263    

  • Yang W#, Bai Y#, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu C ,Yan C, Wang L, Chang C, Chang T, Zhang T, Zhou P Song B, Liu W, Sun S, Liu X, Li B*, Xu C* (2016) Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature. 531(7596): 651-655    

  • Liu W*, Wang H, Xu C* (2016) Antigen Receptor Nanoclusters:Small Units with Big Functions. Trends Immunol. 37(10): 680-689    

  • Wu W, Shi X, Xu C* (2016) Regulation of T cell signalling by membrane lipids. Nat Rev Immunol. 16(11): 690-701    

  • Xu L#, Xia M#, Guo J#, Sun X#, Li H, Xu C, Gu X, Zhang H, Yi J, Fang Y, Xie H, Wang J, Shen Z, Xue B, Sun Y, Meckel T, Chen Y, Hu Z, Li Z*, Xu C*, Gong H*, Liu W* (2016) Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupus-associated polymorphism FcγRIIB-T232. J Exp Med, 213(12): 2707-2727    


  • Wu W#, Yan C#, Shi X, Li L, Liu W, Xu C* (2015) Lipid in T-cell receptor transmembrane signaling. Prog Biophys Mol Biol. 118(3): 130-138    

  • Liu C#, Zhao X#, Xu L, Yi J, Shaheen S, Han W, Wang F, Zheng W, Xu C, Liu W (2015) A negative-feedback function of PKCβ in the formation and accumulation of signaling-active B cell receptor microclusters within B cell immunological synapse. J Leukoc Biol. 97(5): 887-900    

  • Chen X#, Pan W#, Sui Y, Li H, Shi X, Guo X, Qi H, Xu C*, Liu W* (2015) Acidic phospholipids govern the enhanced activation of IgG-B cell receptor. Nature Commun. 6(8552)    


  • Li P, Fu Z, Zhang Y, Zhang J, Xu C, Ma Y, Li B, Song B (2014) The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interaction with NPC1L1. Nat Med. 20(1): 80-86    

  • Wertek F, Xu C* (2014) Digital response in T cells: to be or not to be. Cell Res. 24(3): 265-266    

  • Li L#, Shi X#, Guo X, Li H, Xu C* (2014) Ionic protein-lipid interaction at the plasma membrane: what can the charge do? Trends Biochem Sci. 39(3): 130-140    

  • Wang Y#, Gao J#, Guo X#, Tong T, Shi X, Li L, Qi M, Wang Y, Cai M, Jiang J, Xu C*, Ji H*, Wang H* (2014) Regulation of EGFR nanocluster formation by ionic protein-lipid interaction. Cell Res. 24(8): 959-976    


  • Zhang K#, Pan Y#, Qi J, Yue J, Zhang M, Xu C, Li G*, Chen J* (2013) Disruption of disulfide-restriction at integrin knees induces activation and ligand-independent signaling of α4β7. J Cell Sci. 126(Pt21): 5030-5041    

  • Liu B#, Liu Y#, Du Y, Mardaryev A, Yang W, Chen H, Xu Z, Xu C, Zhang X, Botchkarev V, Zhang Y*, Xu G* (2013) Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 140(4): 780-788    

  • Shi X#, Bi Y#, Yang W#, Guo X, Jiang Y, Wan C, Li L, Bai Y, Guo J, Wang Y, Chen X, Wu B, Sun H, Liu W, Wang J*, Xu C* (2013) Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids. Nature. 493(7430): 111-115    


  • Wang X#, Jimenez-Vargas J#, Xu C, Possani L*, Zhu S* (2012) Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K(+) channel toxins. Biochem Biophys Res Commun. 429(1-2): 111-116    

Selected publications before Xu Lab

  • Xu C, Zhu S, Chi C, Tytgat J, Turret and pore block of K+ channels: what is the difference? (2003) Trends Pharmacol Sci. 24(9): 446-448    

  • Szyk A, Lu W, Xu C, Lubkowski J (2004) Structure of the Scorpion Toxin BmBKTx1 Solved from Single Wavelength Anomalous Scattering of Sulfur. J Struct Biol. 145(3): 289-294    

  • Frénal K#, Xu C#, Wolff N, Wecker K, Gurrola G, Zhu S, Chi C, Possani L, Tytgat J*, Delepierre M* (2004) Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K+ channels. Proteins. 56(2): 367-375    

  • Huys I#, Xu C#, Wang C, Vacher H, Martin-Eauclaire M, Chi C, Tytgat J (2004) BmTx3, a scorpion toxin with two putative functional faces separately active on A-type K+ and HERG currents. Biochem J. 378(3): 45-52    

  • Cai Z#, Xu C#, Xu Y, Lu W, Chi C, Shi Y, Wu J (2004) Solution structure of BmBKTx1, a new BKCa1 channel blocker from the Chinese scorpion Buthus martensi Karsch. Biochemistry. 43(13): 3764-3771    

  • Xu C, He L, Brône B, Martin-Eauclaire M, Van Kerkhove E, Zhou Z, Chi C (2004) A novel scorpion toxin blocking small conductance Ca2+ activated K+ channel. Toxicon. 43(8): 961-971    

  • Xu C#, Brône B#, Wicher D, Bozkurt O, Lu W, Huys I, Han Y, Tytgat J, Van Kerkhove E, Chi C (2004) BmBKTx1, a novel Ca2+activated K+ channel blocker purified from the Asian scorpion Buthus martensi Karsch. J Biol Chem. 279(33): 34562-34569    

  • Jiang H#, Wang C#, Xu C, Fan C, Dai X, Chen J, Chi C (2006) A novel M-superfamily conotoxin with a unique motif from Conus vexillum. Peptides. 27(4): 682-689    

  • Jiang H, Xu C, Wang C, Fan C, Zhao T, Chen J, Chi C (2006) Two novel O-superfamily conotoxins from Conus vexillum. Toxicon. 47(4): 425-436    

  • Call M#, Schnell J#, Xu C, Lutz R, Chou J*, Wucherpfennig K* (2006) The Structure of the ζζ Transmembrane Dimer Reveals Polar Features Essential for Dimerization and Assembly with the T cell Receptor. Cell. 127(2): 355-368    

  • Xu C, Call M, Wucherpfennig K (2006) A membrane-proximal tetracysteine motif contributes to assembly of cd3de and cd3ge dimers with the T cell receptor. J Biol Chem. 281(48): 36977-36984    

  • O’Connor K#, McLaughlin KA#, De Jager P, Chitnis T, Bettelli E, Xu C, Robinson W, Cherry S, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong S, Tavakoli N, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale R, Freedman M, Steinman L, Buckle G, Kuchroo V, Hafler D*, Wucherpfennig K* (2007) Self-assembling Antigen Tetramers Permit Discrimination of Autoantibodies to Folded and Denatured Self-antigens in Demyelinating Diseases. Nat Med. 13(2): 211-217     

  • Wang S, Huang L, Wicher D, Chi C*, Xu C* (2008) Structure-function relationship of bifunctional scorpion toxin BmBKTx1. Acta Biochim Biophys Sin (Shanghai). 40(11): 955-963    

  • Xu C#, Gagnon E#, Call M, Schnell J, Schwieters C, Carman C, Chou J*, Wucherpfennig K* (2008) Regulation of T cell Receptor Activation by Dynamic Membrane Binding of the CD3e Cytoplasmic Tyrosine-Based Motif. Cell. 135(4): 702-713    

  • Gagnon E, Xu C, Yang W, Chu H, Call M, Chou J, Wucherpfennig K* (2010) Response multilayered control of T cell receptor phosphorylation. Cell. 142(5): 669-671